Etiology of Guillain–Barré Syndrome

        What are causes of Guillain–Barré Syndrome? Etiology is still not yet known with certainty and the cause is still a matter of debate. Some conditions / diseases that precede and possibly something to do with the Guillain–Barré Syndrome, among others:

1. Infection
2. Vaccination
3. Surgery
4. Systemic diseases:
    a) malignancy
    b) systemic lupus erythematosus
    c) thyroiditis
    d) Addison's disease
5. Pregnancy or during childbirth
Guillain–Barré Syndrome often associated with acute non-specific. The incidence of Guillain–Barré Syndrome cases associated with this infection approximately between 56% - 80%, which is 1 to 4 weeks before neurological symptoms arise such as an upper respiratory infection or gastrointestinal infection

      It is known that Salmonella typhi infections can cause Guillain–Barré Syndrome. Possibility of Guillain–Barré Syndrome in typhoid fever needs to be known and recognized, especially in Indonesia where typhoid fever is still a major infectious disease.

       Weakness and paralysis that occurs in Guillain–Barré Syndrome caused by the loss of myelin, the material that encloses nerve. The loss of myelin is called demyelinating. Demyelinating caused by nerve impulses delivery has slowed or stopped altogether. Guillain–Barré Syndrome causes inflammation and destruction myelin of some nerves. Therefore, Guillain–Barré Syndrome is also called acute inflammatory demyelinating Polyradiculoneuropathy (AIDP)

      The cause of the inflammation and destruction of the Guillain–Barré Syndrome until now is unknown. There is a mention of the damage caused by autoimmune diseases. In most cases, Guillain–Barré Syndrome preceded by an virus infection  the Epstein-Barr virus, coxsackyvirus, Influenza virus, echovirus, cytomegalovirus, hepatitis virus, and HIV. In addition by viruses, the disease is also preceded by bacteria infection such as Campylobacter jejuni in enteritis, Mycoplasma pneumoniae, Spirochaeta, Salmonella, and Legionella, Mycobacterium Tuberculosa. ; Vaccinations such as BCG, tetanus, varicella, and hepatitis B; systemic diseases such as cancer, lymphoma, collagen disease and sarcoidosis; especially in the third trimester of pregnancy; surgery and epidural anesthesia. Viral infections usually occur 2-4 weeks before any Guillain–Barré Syndrome.


•    Guillain-Barre Syndrome•    Pathophysiology of Guillain-Barré Syndrome•    Clinical Manifestations of Guillain-Barré Syndrome•    Medical Treatment and Therapy of Guillain–Barré syndrome•    How to Diagnose Guillain–Barré syndrome
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