Differential Diagnosis of Syphilis

A. The differential diagnosis of SI (Syphilis I)
        Basic diagnosis of S I as follows. In history it is known mass of incubation; there is no constitutional symptoms, as well as local symptoms ie no pain. In primary affective important there is erosion / ulceration were clean, Solitar, round / oval, regular, with indolent induration: T. pallidum positive. The disorder can be painful if accompanied by secondary infection. Regional nodes may be enlarged, indolent, no groups, no periadenitis, without suppuration. Serologic test after a few weeks of weak positive reaction.

Syphilis Classification and Clinical Manifestations

According to the WHO, syphilis classification are early and late syphilis, with the time difference between the two is two years, and some even say four years. This classification is based on epidemiological considerations. Early syphilis can transmit the disease due to there is Treponema pallidum in skin disorders. Late Syphilis is no longer contagious because there are no bacteria in the lesion. In pregnant women, Treponema pallidum can enter the body of the fetus.

Pathogenesis of Syphilis


A. Early Stage

         In acquired syphilis T.pallidum get into the skin through a micro-lesions or mucous membranes, usually through sex. The germs multiply, tissue reacts by forming infiltrates consisting of lymphocytes and plasma cells, particularly in the perivascular, small blood vessels proliferate, T.pallidum and surrounded by inflammatory cells. Treponema is located between the capillary endothelium and perivascular tissue around it. Loss of bleeding will cause erosion, on clinical examination appear as SI.
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