Treatment and Therapy of Seborrheic Keratosis

A. Drug Therapy

keratolytic agent
Can cause epithelial gore becomes fluffy, soft, maceration then desquamation.
1. Ammonium lactat lotion
Lactic acid and alpha hydroxy acids that have a keratolytic and keratin cells facilitating release . Perfomed 15% and 5% strenght; 12% strenght can cause irritation to the face for making keratin cells do not undergo adhesion.
2. trichloroacetic acid
Burn the skin, keratin and other tissues. May cause local irritation. Seborrheic keratosis treatment with 100% trichloroacetic acid can remove the lesion, but its use must be performed by professionals  skilled hands  .

Therapy can be used topical tazarotene 0.1% cream smear 2 times a day in 16 weeks showed improvement sheboroic keratosis in 7 of 15 patients.

Diagnosis of Seborrheic Keratosis

How To Make Diagnosis Seborrheic Keratosis

Diagnosis obtained through history and physical examination and investigation in the form of histology. Not necessary laboratory tests and radiological examination.
1. History
• Usually asymptomatic, patients complain of a lump of black, feels uncomfortable.
• lesions can sometimes itchy, wanted carded or flops.
• Patients sometimes feels a lump growing slowly.
• Lesions can not heal themselves suddenly.
• The majority of cases there is a family history of inherited.
• Lesions can occur throughout the body except the palms and soles, and mucous membranes.

Pathophysiology and Clinicopathologic Variants of Seborrheic Keratosis


Epidermal Growth Factor (EGF) or its receptor, has been shown to be involved in the formation of seborrheic keratosis. No significant differences of immunoreactive growth hormone receptor expression in epidermal keratinocytes in normal and seborrheic keratosis.
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