Medical Treatment and Therapy of Alzheimer's Disease

Medical Treatment and Therapy of Alzheimer's Disease
        Treatment of Alzheimer's disease is still very limited because of the cause and pathophysiological still unclear. Symptomatic and supportive treatment as only gives a sense of satisfaction in patients. Stimulant medication, vitamins B, C, and E do not have any beneficial effect.

1. Cholinesterase inhibitors
In recent years, many researchers used inhibitors for symptomatic treatment of Alzheimer's disease, in which patients with Alzheimer's found decreased levels of acetylcholine. To prevent decreasing acetylcholine levels can be used anti-cholinesterase which centrally acting like physostigmine, THA (tetrahydroaminoacridine).
This administration, has ability to improve memory and fixing apraxia during administration. Some researchers say that the anti-cholinergic drugs will exacerbate intellectual performance in normal individuals and patients with Alzheimer's.

2. Thiamin
Research has shown that in patients with Alzheimer's found a decrease thiamin pyrophosphatase -dependent enzyme that are ketoglutarate  (75%) and transketolase (45%), this is caused by neuronal damage in the nucleus basalis.
Giving thiamin hydrochlorida a dose of 3 g / day for 3 months orally, showed significant improvement compared to placebo on cognitive function during the same period.

3. Nootropics
Nootropic a psychotropic drug, has been shown to improve cognitive function and learning in experimental animals. But giving 4000 mg in patients with Alzheimer's disease showed no significant clinical improvement.

4. Clonidine
Impaired intellectual functioning in patients with Alzheimer's disease can be caused by damage to cortical noradrenergic. Giving clonidine (Catapres) is an alpha-2 noradrenergic receptor agonist with a maximum dose of 1.2 mg orally for 4 weeks, showed a less satisfactory for improved cognitive function.

5. Haloperidol
In people with Alzheimer's, often occurs psychosis (delusions, hallucinations), and behavior. Haloperidol orally 1-5 mg / day for 4 weeks will improve symptoms. When people with Alzheimer's suffer from depression should be given a tricyclic anti depresant (amitryptiline 25-100 mg / day)

6. Acetyl L-Carnitine (ALC)
It is a subtrate synthesized endogenously in mitochondria with the aid of ALC transferase enzymes. This study showed that ALC can increase the activity of acetyl cholinesterase, choline acetyltransferase.
In giving a dose of 1-2 g / day / orally for 1 year in the treatment, it was concluded that may improve or inhibit the progression of cognitive impairment.

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