Onset of Alzheimer mental changes very slowly, so that patients and families do not know exactly when the disease began to appear. There are several stages of the development of Alzheimer's disease are:
1. Stage I (duration of disease 1-3 years)
• Memory: new learning defective, remote recall mildly impaired
• visuospatial skills: Topographic disorientation, poor contructions complex
• Language: poor woordlist generation, anomia
• Personality: indifference, occasional irritability
• Psychiatry feature: sadness, or delution in some
• Motor system: normal
• EEG: normal
• CT / MRI: normal
• PET / SPECT: bilateral posterior hypometabolism / hyperfusion
2. Stage II (duration of disease 3-10 years)
• Memory: recent and remote recall more Severely impaired
• visuospatial skills: spatial disorientation, poor contructions
• Language: fluent aphasia
• Calculation: acalculation
• Personality: indifference, irritability
• Psychiatry feature: delution in some
• Motor system: restlessness, pacing
• EEG: slow background rhythm
• CT / MRI: normal or ventricular and sulcal enlargeent
• PET / SPECT: bilateral parietal and frontal hypometabolism / hyperfusion
3. Stage III (duration of disease 8-12 years)
• Intellectual function: Severely deteriorated
• Motor system: limb rigidity and flexion poeture
• sphincter control: urinary and fecal
• EEG: diffusely slow
• CT / MRI: ventricular and sulcal enlargeent
• PET / SPECT: bilateral parietal and frontal hypometabolism / hyperfusion
