Intracranial vasoconstriction in the outer cortex plays a role in the occurrence of migraine with aura. This opinion is reinforced by the presence of headache accompanied with the same heart rate. Blood vessels constrict primarily located in the brain due to activation of peripheral nociceptive nerve locals. This theory was initiated above observation that the extracranial veins that will undergo vasodilation palpable heartbeat. This vasodilation will stimulate people to experience headaches. In such conditions, vasoconstrictor drugs, such as ergotamine will reduce headaches, while vasodilators such as nitroglycerin will worsen headaches.